Inositol for Reproductive Health

October 16, 2017; by Briana McDonald, Staff Writer- Silver Bulletin e-News Magazine (UtopiaSilver.com) Many women suffer silently with reproductive health issues such as polycystic ovary syndrome (a hormonal disorder that causes enlarged ovaries with small cysts that grow on the outer edges) and oligomenorrhe  (a condition in which women have infrequent menstrual cycles).PCOS (polycystic ovary syndrome) is responsible for up to 70% of infertility issues in women and leads to other medical issues such as insulin resistance, high cholesterol, high blood pressure and heart disease. Recent studies show that women who suffer with one or both of these conditions and who used inositol for reproductive health had a dramatic improvement in ovarian function over a 14 week period. (1)

 Symptoms of PCOS 
  • weight gain
  • high testosterone levels
  • hair growth in places it shouldn’t grow on the body like face and abdomen
  • changes in mood or behavior
  • low libido
  • irregular periods
  • irregular hair loss and growth
  • acne
  • skin tags
  • infertility
What Causes PCOS? 
 PCOS is the most common hormonal imbalance in women today and estimates show that between 5 and 20% of these sufferers are of childbearing age and unfortunately around 50% are probably misdiagnosed which means millions of women are suffering without any idea why. It is hard to correctly diagnose the disorder because it takes multiple tests to confirm it. Most often it mimics other hormonal disorders such as adrenal fatigue, chronic fatigue, and thyroid disorders. While the disorder can develop for a number of reasons, it is most commonly it is in relationship with insulin resistance in the body.
Inositol for Reproductive Health  
Inositol is a sugar alcohol chemical compound that is naturally found in fruits, beans, grains, and nuts and the foods with the highest concentrations of inositol are cantaloupe and oranges. You can find it in supplement form and our bodies also naturally produce this b-like vitamin.
Recent research supports that therapeutic supplementation with inositol, around 1200-2400 milligrams per day, can greatly improve PCOS symptoms and when combined with healthy changes in diet and lifestyle can even work to reverse the disorder. (2) Many studies who that inositol normalizes menstrual cycles and helps to restore ovulation. Other studies have found that inositol improves egg and embryo quality and increases pregnancy rates in women with PCOS going through in vitro fertilization. (3)
A 2003 study involving 283 patients aimed to conduct a detailed assessment of ovarian activity (2 blood samples per week) to assess the validity of this therapeutic approach in women. Of these 283 patients randomized, 2 withdrew before treatment commenced, 147 received placebo and 136 received inositol (100 mg twice a day) The results showed that the ovulation frequency estimated by the ratio of luteal phase weeks to observation weeks was significanly higher in the treated group (23%) compared with the placebo (13%) The time in which the first ovulation occurred was significanly shorter compared with the number of patients failing to ovulate during the placebo-treatment period was higher in the placebo group and in most cases ovulations were characterized by normal progesterone concentrations in both groups. The effect of inositol on follicular maturation was rapid because the circulating concentration of E2 increased only in the inositol group during the first week of treatment. Significant weight loss and leptin reduction was recorded in the inositol group whereas in the placebo group was recorded an increase of weight. The conclusions of the study supported a beneficial effect of inositol in improving ovarian function in women wtih oligomenorrhea and PCOS.
Going back a little earlier to 1992, Chiu et al published a study about the role of myo-inositol in vitro human fertilization or IVF. The study had a 3-fold aim:
  1. correlate the embryotrophic assayed by post-implantation embryo culture and the inositol levels of several IVF patients with different pregnancy outcomes following IVF
  2. monitoring between cycle variations in embryotrophic properties and inositiol levels of serum samples obtained from patients during normal and treated cycles
  3. investigating the effects of replenishing myo-inositol in serum samples which had previously been found to be non-supportive of mouse embyogenesis
“The study reported an elevated level of inositol in serum samples of patients having successful IVF pregnancies, indicating a possible involvement of inositol in both the early in vitro phase of IVF and the maintenance of normal embryonic development. The findings are consistent with the observation of the teratogenic effect of diabetic patients serum containing low myo-inositol levels, which causes dysmorphogenesis in cultured rodent embryos. Also, using the preimplantation mouse embryo assay to determine the trophic activity of the culture media the authors showed that the serum of patients having successful IVF pregnancies and containing high concentrations of myo-inositol allowed the development of embryos with a greater number of somities.” 4 
Not only can you use inositol for reproductive health but it can help alleviate depression, reduce inflammation, lower blood pressure and also help to lower triglycerides.
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